Article
[Cell culture models of transmissible spongiform encephalopathies].
Comptes rendus biologies - 1 Jan 2002
Lehmann Sylvain, Béranger Florence, Solassol Jérôme, Ceschia Audrey, Perrier Véronique, De Gassart Aude, Vilette Didier, Laude Hubert, Kellermann Odile, Mangé Alain
Abstract excerpt
Cell cultures represent versatile and useful experimental models of transmissible spongiform encephalopathies. These models include chronically prion infected cell lines, as well as cultures expressing variable amounts of wild-type, mutated or chimeric prion proteins. These cultures have been widely used to investigate the biology of both the normal and the pathological isoform of the prion protein. They have...
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