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Article

PrP polymorphisms tightly control sheep prion replication in cultured cells.

Journal of virology - 1 Feb 2003

Sabuncu Elifsu, Petit Stéphanie, Le Dur Annick, Lan Lai Thanh, Vilotte Jean-Luc, Laude Hubert, Vilette Didier

Abstract excerpt

Prion diseases are fatal neurodegenerative disorders of animals and humans that are characterized by the conversion of the host-encoded prion protein (PrP) to an abnormal isoform. In several species, including humans, polymorphisms in the gene encoding the PrP protein tightly control susceptibility of individuals toward this disease. In the present study we show that Rov cells expressing an ovine PrP allele...

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Identifiers

PMID: 12552009
DOI: 10.1128/jvi.77.4.2696-2700.2003
PMCID: PMC141085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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