Article

Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line

2020-04-01

Abstract excerpt

Transmission of prion infectivity to susceptible murine cell lines has simplified prion titration assays and has greatly reduced the need for animal experimentation. However, murine cell models suffer from technical and biological constraints. Human cell lines might be more useful, but they are much more biohazardous and are often poorly infectible. Here we describe the human clonal cell line hovS, which lacks the...

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Literature Corpus work: e1d15c7f-1b9a-5da7-99e3-dd08de52f40c
DOI: 10.1101/2020.04.01.019786

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