Article
Expression of the seqA gene is negatively modulated by the HU protein in Escherichia coli.
Molecular & general genetics : MGG - 1 Feb 2001
Lee H, Kim H K, Kang S, Hong C B, Yim J, Hwang D S
Abstract excerpt
The SeqA protein acts as a regulator of chromosomal replication initiation in Escherichia coli by sequestering hemi-methylated oriC, effectively blocking methylation and therefore preventing rapid re-initiation. The level of SeqA protein is maximal at mid-log phase and decreases when cells enter late-log phase. In hup mutants that lack the HU protein, the maximal seqA expression is also seen at mid-log phase, but...
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