Article
The Escherichia coli SeqA protein.
Plasmid - 1 May 2009
Waldminghaus Torsten, Skarstad Kirsten
Abstract excerpt
The Escherichia coli SeqA protein contributes to regulation of chromosome replication by preventing re-initiation at newly replicated origins. SeqA protein binds to new DNA which is hemimethylated at the adenine of GATC sequences. Most of the cellular SeqA is found complexed with the new DNA at the replication forks. In vitro the SeqA protein binds as a dimer to two GATC sites and is capable of forming a helical...
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