Article
SeqA: a negative modulator of replication initiation in E. coli.
Cell - 6 May 1994
Lu M, Campbell J L, Boye E, Kleckner N
Abstract excerpt
In E. coli, replication initiates at a genetically unique origin, oriC. Rapidly growing cells contain multiple oriC copies. Initiation occurs synchronously, once and only once per cell cycle at all origins present. Secondary initiations are prevented by a sequestration process that acts uniquely on newly replicated origins, which are marked because they are hemimethylated at GATC sites. We report the...
Topics
- Amino Acid Sequence
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Base Sequence
- Chromosomes, Bacterial
- Cloning, Molecular
- DNA Replication
- DNA, Bacterial
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins