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Article

SeqA: a negative modulator of replication initiation in E. coli.

Cell - 6 May 1994

Lu M, Campbell J L, Boye E, Kleckner N

Abstract excerpt

In E. coli, replication initiates at a genetically unique origin, oriC. Rapidly growing cells contain multiple oriC copies. Initiation occurs synchronously, once and only once per cell cycle at all origins present. Secondary initiations are prevented by a sequestration process that acts uniquely on newly replicated origins, which are marked because they are hemimethylated at GATC sites. We report the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8011018
DOI: 10.1016/0092-8674(94)90156-2

Genes

GATC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SeqA: a negative modulator of replication initiation in E. coli.PMID 8011018Read ↗

Coordinating DNA replication initiation with cell growth: differential roles for DnaA and SeqA proteins.Semantic proximity Read ↗

SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor.Semantic proximity Read ↗

A role for nonessential domain II of initiator protein, DnaA, in replication control.Semantic proximity Read ↗

Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein.Semantic proximity Read ↗

SeqA limits DnaA activity in replication from oriC in Escherichia coli.Semantic proximity Read ↗

Lack of SeqA focus formation, specific DNA binding and proper protein multimerization in the Escherichia coli sequestration mutant seqA2.Semantic proximity Read ↗

The Escherichia coli SeqA protein.Semantic proximity Read ↗

Eclipse-synchrony relationship in Escherichia coli strains with mutations affecting sequestration, initiation of replication and superhelicity of the bacterial chromosome.Semantic proximity Read ↗

Organization of sister origins and replisomes during multifork DNA replication in Escherichia coli.Semantic proximity Read ↗

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