Article
The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction.
PloS one - 1 Jan 2009
Oberto Jacques, Nabti Sabrina, Jooste Valérie, Mignot Hervé, Rouviere-Yaniv Josette
Abstract excerpt
BACKGROUND: The Escherichia coli heterodimeric HU protein is a small DNA-bending protein associated with the bacterial nucleoid. It can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Cells lacking HU grow very poorly and display many phenotypes. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the transcription profile of every Escherichia coli gene in the absence of one or...
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