Article
The Escherichia coli SeqA protein destabilizes mutant DnaA204 protein.
Molecular microbiology - 1 Aug 2000
Torheim N K, Boye E, Løbner-Olesen A, Stokke T, Skarstad K
Abstract excerpt
In wild-type Escherichia coli cells, initiation of DNA replication is tightly coupled to cell growth. In slowly growing dnaA204 (Ts) mutant cells, the cell mass at initiation and its variability is increased two- to threefold relative to wild type. Here, we show that the DnaA protein concentration was two- to threefold lower in the dnaA204 mutant compared with the wild-type strain. The reason for the DnaA protein...
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