Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1.

doi:10.1093/carcin/17.11.2347

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Article

Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1.

Carcinogenesis - 1 Nov 1996

Dycaico M J, Stuart G R, Tobal G M, de Boer J G, Glickman B W, Provost G S

Abstract excerpt

In vivo mutations were studied in lambda/lacI (Big Blue) transgenic C57BL/6 mice and F344 rats following exposure to either AFB1 (aflatoxin B1) or DMSO vehicle. Fourteen days after exposure, livers were removed for DNA extraction and subsequent mutational analysis of the lacI gene. Mice injected...

Topics

Aflatoxin B1
Animals
Bacterial Proteins
Bacteriophage lambda
DNA
DNA Mutational Analysis
Escherichia coli Proteins
Female
Lac Repressors
Liver
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Transgenic

Mutagens

Mutation

Rats

Rats, Inbred F344

Source

Open in PubMed

Identifiers

PMID: 8968048
DOI: 10.1093/carcin/17.11.2347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8968048-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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