Article
Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats.
Mutation research - 10 Jun 1996
de Boer J G, Erfle H, Holcroft J, Walsh D, Dycaico M, Provost S, Short J, Glickman B W
Abstract excerpt
The finding of a large discordance between animal species in their response to a carcinogenic challenge, has led to the realization that the useful extrapolation of animal test data to humans requires a better understanding of animal interspecies differences. With the development of transgenic shuttle vector based animal systems we are now able to study mutation of the same genetic target in both mice and rats....
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