Article
Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats.
Mutation research - 10 Jun 1996
de Boer J G, Erfle H, Holcroft J, Walsh D, Dycaico M, Provost S, Short J, Glickman B W
Abstract excerpt
The finding of a large discordance between animal species in their response to a carcinogenic challenge, has led to the realization that the useful extrapolation of animal test data to humans requires a better understanding of animal interspecies differences. With the development of transgenic sh...
Topics
- Animals
- Animals, Genetically Modified
- Bacterial Proteins
- Base Sequence
- DNA
- DNA Mutational Analysis
- Databases, Factual
- Escherichia coli Proteins
- Female
- Gene Dosage
- Genetic Vectors
- Germ Cells
- Humans
- Lac Repressors
- Liver
- Male
- Mice
- Mice, Transgenic