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Article

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.

Cancer research - 15 Feb 2001

Gökmen-Polar Y, Murray N R, Velasco M A, Gatalica Z, Fields A P

Abstract excerpt

Protein kinase C (PKC) has been implicated in colon carcinogenesis in humans and in rodent models. However, little is known about the specific role of individual PKC isozymes in this process. We recently demonstrated that elevated expression of PKC betaII in the colonic epithelium induces hyperproliferation in vivo (N. R. Murray et al., J. Cell Biol., 145: 699-711, 1999). Because hyperproliferation is a major...

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PMID: 11245437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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