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Article

Colon fibroblasts from Pirc rats (F344/NTac-Apcam1137 ) exhibit a proliferative and inflammatory phenotype that could support early stages of colon carcinogenesis.

International journal of cancer - 15 Jan 2022

Tortora Katia, Margheri Francesca, Luceri Cristina, Mocali Alessandra, Ristori Sara, Magnelli Lucia, Caderni Giovanna, Giovannelli Lisa

Abstract excerpt

The role of fibroblast APC mutation in carcinogenesis is not clear. Apc+/- colon fibroblasts have been previously characterized: however, little is known about their behavior at very early-stage of colon carcinogenesis. We cultured colon mucosa fibroblasts (PCF, Apc+/- ) of Pirc rats (F344/NTac-Apcam1137 ) at an early stage of tumorigenesis, in absence of preneoplastic lesions, and of age-matched wt (WCF): DNA...

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Identifiers

PMID: 34486752
DOI: 10.1002/ijc.33796
PMCID: PMC9291568

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