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Article

Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci.

Cancer research - 1 Jun 2006

Cohen Greg, Mustafi Reba, Chumsangsri Anusara, Little Nathaniel, Nathanson Jeff, Cerda Sonia, Jagadeeswaran Sujatha, Dougherty Urszula, Joseph Loren, Hart John, Yerian Lisa, Tretiakova Maria, Yuan Weihua, Obara Piotr, Khare Sharad, Sinicrope Frank A, Fichera Alessandro, Boss Gerry R, Carroll Robert, Bissonnette Marc

Abstract excerpt

Aberrant crypt foci (ACF) are collections of abnormal colonic crypts with heterogeneous molecular and pathologic characteristics. Large and dysplastic ACF are putative precursors of colon cancer with neoplastic risk related to increased proliferation. In this study, we examined the role of epider...

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Identifiers

PMID: 16740703
DOI: 10.1158/0008-5472.CAN-05-0308

Genes

EGFR
PCNA
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16740703-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci.PMID 16740703Read ↗

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