Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.

The Journal of biological chemistry - 21 May 2004

Zhang Jie, Anastasiadis Panos Z, Liu Yan, Thompson E Aubrey, Fields Alan P

Abstract excerpt

Protein kinase C betaII (PKCbetaII) promotes colon carcinogenesis. Expression of PKCbetaII in the colon of transgenic mice induces hyperproliferation and increased susceptibility to colon cancer. To determine molecular mechanisms by which PKCbetaII promotes colon cancer, we established rat intestinal epithelial (RIE) cells stably expressing PKCbetaII. Here we show that RIE/PKCbetaII cells acquire an invasive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butadienes
Share to MAP Kinase Kinase Kinase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to MAP Kinase Kinase Kinases

Share to Mesylates

Share to p21-Activated Kinases

Share to Prostaglandin-Endoperoxide Synthases

Share to Protein Kinase C beta

Share to rac1 GTP-Binding Protein

Source

Identifiers

PMID: 15037605
DOI: 10.1074/jbc.M400774200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.PMID 15037605Read ↗

The PKC universe keeps expanding: From cancer initiation to metastasis.Semantic proximity Read ↗

The complexities of PKCα signaling in cancer.Semantic proximity Read ↗

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.Semantic proximity Read ↗

Protein Kinase C-ε Promotes EMT in Breast CancerSemantic proximity Read ↗

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.Semantic proximity Read ↗

PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65Semantic proximity Read ↗

Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switchSemantic proximity Read ↗

A RAC-GEF network critical for early intestinal tumourigenesis.Semantic proximity Read ↗

PKCζ, MMP‑2 and MMP‑9 expression in lung adenocarcinoma and association with a metastatic phenotype.Semantic proximity Read ↗

Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.Semantic proximity Read ↗

Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis.Semantic proximity Read ↗

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.