Article
The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace.
Clinical biochemistry - 1 Feb 2001
Ongagna J C, Kaltenbacher M C, Sapin R, Pinget M, Belcourt A
Abstract excerpt
BACKGROUND: The HLA-DQB1 chain, in particular the amino acid in position 57, and genetic variants of the vitamin D-binding protein (DBP) have been reported to be associated with type 1 diabetes. There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: codons 416 GAT --> GAG (Asp --> Glu) and 420 ACG --> AAG (Thr --> Lys). We compared distribution of DQB1 alleles and amino...
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