Article
Amino acid variants of the vitamin D-binding protein and risk of diabetes in white Americans of European origin.
European journal of endocrinology - 1 Nov 1999
Klupa T, Malecki M, Hanna L, Sieradzka J, Frey J, Warram J H, Sieradzki J, Krolewski A S
Abstract excerpt
BACKGROUND: Genetic variants of vitamin D-binding protein (DBP) have been reported to be associated, not only with diabetes, but also with prediabetic traits, in several populations. There are two known polymorphisms in exon 11 of the DBP gene that result in amino acid variants: at codons 416 GAT-->GAG (Asp-->Glu) and 420 ACG-->AAG (Thr-->Lys). OBJECTIVE: To examine the association of these polymorphisms with...
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