Article
Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes.
International journal of experimental diabetes research - 1 Jan 2002
Ongagna Jean Claude, Sapin Remi, Pinget Michel, Belcourt Alain
Abstract excerpt
BACKGROUND: The cytotoxic T lymphocyte-associated antigen 4 gene (CTLA-4) encode the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. The receptor protein is a specific T lymphocyte surface antigen that is detected on cells only after antigen presentation. Thus, CTLA-4 is directly involved in both immune and autoimmune responses and may be involved in the pathogenesis...
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