Article
HLA-DQA1 and DQB1 gene polymorphisms in type I diabetic patients from central Italy and their use for risk prediction.
Diabetes - 1 Aug 1993
Buzzetti R, Nisticò L, Osborn J F, Giovannini C, Chersi A, Sorrentino R
Abstract excerpt
Susceptibility to type I diabetes has been shown to be highly correlated with the presence of an amino acid other than Asp at position 57 of the DQ beta-chain (non-Asp57) and also with the presence of an Arg at position 52 of the DQ alpha-chain (Arg52). In this study we analyzed the DQA1 and DQB1...
Topics
- Adolescent
- Alleles
- Base Sequence
- Diabetes Mellitus, Type 1
- Female
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Humans
- Incidence
- Italy
- Male
- Molecular Sequence Data
- Odds Ratio
- Polymorphism, Genetic
- Predictive Value of Tests
- Prevalence
- Probucol