Cystic fibrosis-related diabetes is associated with HLA DQB1 alleles encoding Asp-57- molecules.

doi:10.1007/BF01546319

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Article

Cystic fibrosis-related diabetes is associated with HLA DQB1 alleles encoding Asp-57- molecules.

Journal of clinical immunology - 1 Nov 1994

Carrington M, Krueger L J, Holsclaw D S, Iannuzzi M C, Dean M, Mann D

Abstract excerpt

The incidence of insulin-dependent diabetes in individuals with cystic fibrosis is nearly 100 times greater than in the general population. In the latter group, strong associations with specific HLA DQA1 and DQB1 alleles have been observed. To determine if a similar distribution of alleles occurs...

Topics

Adolescent
Adult
Alleles
Base Sequence
Child
Cystic Fibrosis
Diabetes Mellitus, Type 1
Female
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation

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