Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals of different populations to type I diabetes.

doi:10.1002/(sici)1096-8628(19980305)76:2<183::aid-ajmg12>3.0.co;2-h

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Article

Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals of different populations to type I diabetes.

American journal of medical genetics - 5 Mar 1998

Zamani M, Cassiman J J

Abstract excerpt

Several publications have shown that certain alleles at the HLA-DRB1, -DQA1, and -DQB1 loci are associated with insulin-dependent diabetes mellitus (IDDM). Many of these studies have claimed that HLA-DQalpha1Arg52 and DQbeta1Asp57 showed the strongest association with IDDM, but these results coul...

Topics

Alleles
Amino Acids
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Gene Frequency
Genotype
Haplotypes
Histocompatibility Antigens Class II
Humans
Male
Polymorphism, Genetic

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