Article
Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Dorman J S, LaPorte R E, Stone R A, Trucco M
Abstract excerpt
The presence of an amino acid other than aspartic acid at position 57 of the HLA-DQ beta chain (non-Asp-57) is highly associated with susceptibility to insulin-dependent diabetes mellitus (IDDM), whereas an aspartic acid at this position (Asp-57) appears to confer resistance to the disease. We hypothesize that the 30-fold difference in IDDM incidence across racial groups and countries is related to variability in...
Topics
- Adolescent
- Alleles
- Amino Acids
- Base Sequence
- DNA
- Diabetes Mellitus, Type 1
- Gene Frequency
- Genetic Variation
- Genotype
- HLA-DQ Antigens
- HLA-DQ beta-Chains