Article
Stop codons affect 5' splice site selection by surveillance of splicing.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Li Binghui, Wachtel Chaim, Miriami Elana, Yahalom Galit, Friedlander Gilgi, Sharon Gil, Sperling Ruth, Sperling Joseph
Abstract excerpt
Pre-mRNA splicing involves recognition of a consensus sequence at the 5' splice site (SS). However, only some of the many potential sites that conform to the consensus are true ones, whereas the majority remain silent and are not normally used for splicing. We noticed that in most cases the utilization of such a latent intronic 5' SS for splicing would introduce an in-frame stop codon into the resultant mRNA....
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