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Article

Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.

Cell - 3 May 2002

Lallena María José, Chalmers Kevin J, Llamazares Salud, Lamond Angus I, Valcárcel Juan

Abstract excerpt

The Drosophila protein Sex-lethal (SXL) promotes skipping of exon 3 from its own pre-mRNA. An unusual sequence arrangement of two AG dinucleotides and an intervening polypyrimidine (Py)-tract at the 3' end of intron 2 is important for Sxl autoregulation. Here we show that U2AF interacts with the Py-tract and downstream AG, whereas the spliceosomal protein SPF45 interacts with the upstream AG and activates it for...

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PMID: 12015979
DOI: 10.1016/s0092-8674(02)00730-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.PMID 12015979Read ↗

Sex, AGility, and the regulation of alternative splicing.Semantic proximity Read ↗

SPF45/RBM17-dependent, but not U2AF-dependent, splicing in human short intronsSemantic proximity Read ↗

SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short intronsSemantic proximity Read ↗

Interactions of SR45, an SR-like protein, with spliceosomal proteins and an intronic sequence: insights into regulated splicing.Semantic proximity Read ↗

Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination.Semantic proximity Read ↗

Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.Semantic proximity Read ↗

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.Semantic proximity Read ↗

A conditional role of U2AF in splicing of introns with unconventional polypyrimidine tracts.Semantic proximity Read ↗

PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila.Semantic proximity Read ↗

The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein.Semantic proximity Read ↗

Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.Semantic proximity Read ↗

Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.Semantic proximity Read ↗

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