Article
Rats made congenic for Oia3 on chromosome 10 become susceptible to squalene-induced arthritis.
Human molecular genetics - 15 Mar 2001
Holm B C, Xu H W, Jacobsson L, Larsson A, Luthman H, Lorentzen J C
Abstract excerpt
Several quantitative trait loci (QTLs) regulating the risk of experimental arthritis have been identified by genome-wide linkage analyses, but only the MHC has thus far been reported to transfer arthritis susceptibility in congenic animals. We have produced a congenic strain for Oia3, a genetic factor originally identified as an oil-induced arthritis (OIA) QTL in arthritis-prone DA rats. A 46 cM telomeric region...
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