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Article

The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats.

The American journal of pathology - 1 Jun 2000

Carlson B C, Jansson A M, Larsson A, Bucht A, Lorentzen J C

Abstract excerpt

Squalene is a cholesterol precursor, which stimulates the immune system nonspecifically. We demonstrate that one intradermal injection of this adjuvant lipid can induce joint-specific inflammation in arthritis-prone DA rats. Histopathological and immunohistochemical analyses revealed erosion of bone and cartilage, and that development of polyarthritis coincided with infiltration of alphabeta(+) T cells. Depletion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10854227
DOI: 10.1016/S0002-9440(10)65077-8
PMCID: PMC1850095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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