Article
The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.
The EMBO journal - 1 Mar 2001
Lim J H, Martin F, Guiard B, Pfanner N, Voos W
Abstract excerpt
Unfolding is an essential process during translocation of preproteins into mitochondria; however, controversy exists as to whether mitochondria play an active role in unfolding. We have established an in vitro system with a kinetic saturation of the mitochondrial import machinery, yielding translocation rates comparable to in vivo import rates. Preproteins with short N-terminal segments in front of a folded...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.