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Article

Mitochondrial Hsp70/MIM44 complex facilitates protein import.

Nature - 27 Oct 1994

Schneider H C, Berthold J, Bauer M F, Dietmeier K, Guiard B, Brunner M, Neupert W

Abstract excerpt

Protein translocation into mitochondria requires the mitochondrial protein Hsp70. This molecular chaperone of the mitochondrial matrix is recruited to the protein import machinery by MIM44, a component associated with the inner membrane of the mitochondria. Formation of the mt-Hsp70/MIM44 complex is regulated by ATP. MIM44 and mt-Hsp 70 interact in a sequential manner with incoming segments of unfolded...

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PMID: 7935837
DOI: 10.1038/371768a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mitochondrial Hsp70/MIM44 complex facilitates protein import.PMID 7935837Read ↗

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.Semantic proximity Read ↗

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.Semantic proximity Read ↗

The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.Semantic proximity Read ↗

The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.Semantic proximity Read ↗

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.Semantic proximity Read ↗

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.Semantic proximity Read ↗

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.Semantic proximity Read ↗

Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix.Semantic proximity Read ↗

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.Semantic proximity Read ↗

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.Semantic proximity Read ↗

Protein unfolding by the mitochondrial membrane potential.Semantic proximity Read ↗

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