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Article

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.

The Journal of cell biology - 1 Dec 1994

Rassow J, Maarse A C, Krainer E, Kübrich M, Müller H, Meijer M, Craig E A, Pfanner N

Abstract excerpt

The import of preproteins into mitochondria involves translocation of the polypeptide chains through putative channels in the outer and inner membranes. Preprotein-binding proteins are needed to drive the unidirectional translocation of the precursor polypeptides. Two of these preprotein-binding proteins are the peripheral inner membrane protein MIM44 and the matrix heat shock protein hsp70. We report here that...

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Identifiers

PMID: 7798311
DOI: 10.1083/jcb.127.6.1547
PMCID: PMC2120292

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Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.PMID 7798311Read ↗

Mitochondrial Hsp70/MIM44 complex facilitates protein import.Semantic proximity Read ↗

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.Semantic proximity Read ↗

The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.Semantic proximity Read ↗

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.Semantic proximity Read ↗

The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.Semantic proximity Read ↗

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.Semantic proximity Read ↗

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.Semantic proximity Read ↗

Interaction of the J-protein heterodimer Pam18/Pam16 of the mitochondrial import motor with the translocon of the inner membrane.Semantic proximity Read ↗

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.Semantic proximity Read ↗

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.Semantic proximity Read ↗

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.Semantic proximity Read ↗

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