Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.

doi:10.1083/jcb.127.6.1547

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Article

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.

The Journal of cell biology - 1 Dec 1994

Rassow J, Maarse A C, Krainer E, Kübrich M, Müller H, Meijer M, Craig E A, Pfanner N

Abstract excerpt

The import of preproteins into mitochondria involves translocation of the polypeptide chains through putative channels in the outer and inner membranes. Preprotein-binding proteins are needed to drive the unidirectional translocation of the precursor polypeptides. Two of these preprotein-binding proteins are the peripheral inner membrane protein MIM44 and the matrix heat shock protein hsp70. We report here that...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Biological Transport
Carrier Proteins
Cell Compartmentation
Cross-Linking Reagents
Fungal Proteins
HSP40 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Membrane Transport Proteins

Mitochondria

Mitochondrial Membrane Transport Proteins

Mitochondrial Precursor Protein Import Complex Proteins

Molecular Sequence Data

Mutation

Precipitin Tests

Source

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Identifiers

PMID: 7798311
DOI: 10.1083/jcb.127.6.1547
PMCID: PMC2120292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7798311-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44.PMID 7798311Read ↗

Mitochondrial Hsp70/MIM44 complex facilitates protein import.Semantic proximity Read ↗

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.Semantic proximity Read ↗

The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.Semantic proximity Read ↗

A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins.Semantic proximity Read ↗

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase.Semantic proximity Read ↗

Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.Semantic proximity Read ↗

Interaction of the J-protein heterodimer Pam18/Pam16 of the mitochondrial import motor with the translocon of the inner membrane.Semantic proximity Read ↗

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.Semantic proximity Read ↗

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

Mitochondrial GrpE modulates the function of matrix Hsp70 in translocation and maturation of preproteins.Semantic proximity Read ↗

Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.Semantic proximity Read ↗

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