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Article

Functional coupling of presequence processing and degradation in human mitochondria.

The FEBS journal - 1 Jan 2021

Kücükköse Cansu, Taskin Asli Aras, Marada Adinarayana, Brummer Tilman, Dennerlein Sven, Vögtle Friederike-Nora

Abstract excerpt

The mitochondrial proteome is built and maintained mainly by import of nuclear-encoded precursor proteins. Most of these precursors use N-terminal presequences as targeting signals that are removed by mitochondrial matrix proteases. The essential mitochondrial processing protease MPP cleaves presequences after import into the organelle thereby enabling protein folding and functionality. The cleaved presequences...

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PMID: 32491259
DOI: 10.1111/febs.15358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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