Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of mechanism of acquired skewed X inactivation by analysis of twins.

Blood - 1 Mar 2001

Vickers M A, McLeod E, Spector T D, Wilson I J

Abstract excerpt

Skewed X-chromosome inactivation in peripheral blood granulocytes becomes more frequent with increasing age, affecting up to half of those over 75 years old. To investigate the mechanisms underlying this phenomenon, X-inactivation profiles in 33 monozygotic and 22 dizygotic elderly twin pairs were studied. Differential methylation-sensitive restriction enzyme cutting at a hypervariable locus in the human androgen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Granulocytes
Share to Hematopoiesis
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Stochastic Processes

Share to Twins, Dizygotic

Share to Twins, Monozygotic

Share to X Chromosome

Source

Identifiers

PMID: 11222370
DOI: 10.1182/blood.v97.5.1274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of mechanism of acquired skewed X inactivation by analysis of twins.PMID 11222370Read ↗

Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach.Semantic proximity Read ↗

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with ageSemantic proximity Read ↗

Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humansSemantic proximity Read ↗

Directional X Chromosome Skewing of White Blood Cells from Subjects with Heterozygous Mosaicism for the Variant IRAK1 Haplotype.Semantic proximity Read ↗

Skewed X inactivation in healthy individuals and in different diseasesSemantic proximity Read ↗

Heritability of skewed X-inactivation in female twins is tissue-specific and dependent on ageSemantic proximity Read ↗

Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromesSemantic proximity Read ↗

Diminished sex hormone levels influence the risk of skewed X chromosome inactivationSemantic proximity Read ↗

TRiXi: A Multi-Target Tandem Repeat-Based Method for Accurate Detection of X-Inactivation Skewing in HumansSemantic proximity Read ↗

Hematopoiesis is not clonal in healthy elderly women.Semantic proximity Read ↗

Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay.Semantic proximity Read ↗

Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.