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Article

Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromes

1 Jun 1997

Abstract excerpt

Studies of X chromosome inactivation patterns are central to many aspects of our understanding of the pathogenesis of haematological malignancies. In patients with myeloproliferative disorders and myelodysplastic syndromes the demonstration of skewed X inactivation patterns in multiple haemopoietic lineages has been taken to indicate a stem cell origin for these groups of diseases. However, stem cell depletion or...

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PMID: 9217198
DOI: 10.1046/j.1365-2141.1997.1933010.x

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Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromesPMID 9217198Read ↗

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Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase geneSemantic proximity Read ↗

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Clinical significance of Y chromosome loss in hematologic diseaseSemantic proximity Read ↗

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