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Article

Hematopoiesis is not clonal in healthy elderly women.

Blood - 15 Oct 2008

Swierczek Sabina I, Agarwal Neeraj, Nussenzveig Roberto H, Rothstein Gerald, Wilson Andrew, Artz Andrew, Prchal Josef T

Abstract excerpt

Clonality assays, based on X-chromosome inactivation, discriminate active from inactive alleles. Skewing of X-chromosome allelic usage, based on preferential methylation of one of the HUMARA alleles, was reported as evidence of clonal hematopoiesis in approximately 30% of elderly women. Using a quantitative, transcriptionally based clonality assay, we reported X-chromosome-transcribed allelic ratio in blood cells...

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Topics

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Share to Aged, 80 and over
Share to Case-Control Studies
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Hematopoiesis

Share to Receptors, Androgen

Share to Transcription, Genetic

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 18641369
DOI: 10.1182/blood-2008-03-143925
PMCID: PMC2569172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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