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Article

Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay.

Journal of medical genetics - 1 Feb 2013

Mossner Maximilian, Nolte Florian, Hütter Gero, Reins Jana, Klaumünzer Marion, Nowak Verena, Obländer Julia, Ackermann Katrin, Will Silke, Röhl Henning, Neumann Uwe, Neumann Martin, Hopfer Olaf, Baldus Claudia D, Hofmann Wolf-Karsten, Nowak Daniel

Abstract excerpt

BACKGROUND: Investigation of X-chromosome inactivation patterns (XCIP) by determination of differential CpG-methylation has been widely applied for investigation of female cell clonality. Using this approach the clonal origin of various tumours has been corroborated. Controversially, strong age-related increase of peripheral blood (PB) cell clonality in haematologically healthy female subjects was reported....

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PMID: 23339109
DOI: 10.1136/jmedgenet-2012-101093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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