Article
Evidence for two modes of allelic loss: multifocal analysis on both early and advanced gastric carcinomas.
Virchows Archiv : an international journal of pathology - 1 Jan 2001
Chung Y J, Choi J R, Park S W, Kim K M, Rhyu M G
Abstract excerpt
To assess the extent and the timing of allelic loss required for the progression of gastric carcinoma, the intratumoral distribution of loss of heterozygosity (LOH) was compared in early and advanced tumors: early loss is uniformly observed in all tumor areas and late loss is localized in parts of tumor tissue. Tumor sites (167 sites) obtained from 42 gastric carcinoma tissues (26 advanced cancers and 16 early...
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