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Article

Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease.

Cellular and molecular life sciences : CMLS - 15 Oct 1999

Tomiyama T, Corder E H, Mori H

Abstract excerpt

Apolipoprotein E (apoE) epsilon4 allele is a genetic risk factor for late-onset familial and sporadic Alzheimer's disease (AD). In the central nervous system, apoE is secreted mainly by astrocytes as a constituent of high-density lipoproteins. A recent study using apoE knockout mice provided strong evidence that apoE promotes cerebral deposition of amyloid beta protein (Abeta). However, no clear explanation of...

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Identifiers

PMID: 11212354
DOI: 10.1007/s000180050428
PMCID: PMC11146988

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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