Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms.

Abstract excerpt

The three common apolipoprotein E (ApoE) alleles differentially contribute to the risk of Alzheimer's disease (AD). While the APOE genotype alters susceptibility to disease expression, individuals with APOE epsilon 4 alleles have the highest risk of developing AD; the APOE epsilon 4 allele is neither essential nor sufficient on its own to cause AD. Since the discovery, in 1992, of the involvement of APOE in AD,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Calcium Signaling
• Share to CD36 Antigens
• Share to Low Density Lipoprotein Receptor-Related Protein-1