The use of mixture models to perform quantitative tests for linkage disequilibrium, maternal effects, and parent-of-origin effects with incomplete subject-parent triads.

Abstract excerpt

The transmission disequilibrium test and related methods require complete triads of genotyped cases plus both parents to test for linkage disequilibrium in the presence of population stratification. Based on the work of Weinberg (1999ab) and Schaid and Li (1997) with dichotomous outcomes, we discuss how additional tests for maternal or parent-of-origin effects can be performed and incomplete subject-parent triads...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Linkage Disequilibrium
• Share to Models, Genetic