Testing informative missingness in genetic studies using case-parent triads.

doi:10.1038/ejhg.2008.38

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Testing informative missingness in genetic studies using case-parent triads.

European journal of human genetics : EJHG - 1 Aug 2008

Guo Chao-Yu, Cupples Laura Adrienne, Yang Qiong

Abstract excerpt

In genetic studies, the transmission/disequilibrium test (TDT) using case-parent triads has gained popularity attributable to its robustness to population admixture. Several extensions have been proposed to accommodate incomplete triads. Some strategies assume that parental genotypes are missing completely at random (MCAR) to insure an unbiased conclusion and some methods allow parental genotypes to be missing...

Topics

Apolipoproteins E
Computer Simulation
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Genetic Testing
Humans
Linkage Disequilibrium
Male
Models, Genetic
Models, Statistical
Parents
Probability

Source

Open in PubMed

Identifiers

PMID: 18337731
DOI: 10.1038/ejhg.2008.38

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics