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Article

Impact of non-ignorable missingness on genetic tests of linkage and/or association using case-parent trios.

BMC genetics - 30 Dec 2005

Guo Chao-Yu, Cui Jing, Cupples L Adrienne

Abstract excerpt

The transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. When parental information is non-randomly missing, due, for example, to death from the disease under study, the impact on type I error and power under dominant and recessive disease models has...

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Share to Genes, Dominant
Share to Genes, Recessive
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Testing

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Share to Quantitative Trait, Heritable

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Identifiers

PMID: 16451706
DOI: 10.1186/1471-2156-6-S1-S90
PMCID: PMC1866689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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