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Article

The reverse transcriptase model of somatic hypermutation.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Steele E J, Blanden R V

Abstract excerpt

The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over...

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Identifiers

PMID: 11205332
DOI: 10.1098/rstb.2000.0749
PMCID: PMC1087692

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Source receipt: pubmed, retrieved 7 Sept 2026.

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