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Article

RNA-directed DNA repair and antibody somatic hypermutation.

Trends in genetics : TIG - 1 May 2022

Franklin Andrew, Steele Edward J

Abstract excerpt

Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) pairs. Deamination of C to deoxyuridine (U) by activation-induced deaminase (AID) explains how mutation at C/G pairs is potentiated. Mutation at A/T pairs is triggered during the initial stages of repair of AID-generated U lesions and occurs through an as yet unknown mechanism in which...

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Identifiers

PMID: 34740453
DOI: 10.1016/j.tig.2021.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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