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Article

Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Storb U, Shen H M, Michael N, Kim N

Abstract excerpt

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM. Presumably, cis-acting elements, such as those present in the Ig enhancers, are required to target a mutator factor (MuF) to Ig and human BCL-6 genes. It is...

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Identifiers

PMID: 11205325
DOI: 10.1098/rstb.2000.0743
PMCID: PMC1087686

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Source receipt: pubmed, retrieved 7 Sept 2026.

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