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Article

Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Diaz M, Flajnik M F, Klinman N

Abstract excerpt

Somatic hypermutation of immunoglobulin genes occurs in many vertebrates including sharks, frogs, camels, humans and mice. Similarities among species reveal a common mechanism and these include the AGC/T sequence hot spot, preponderance of base substitutions, a bias towards transitions and strand...

Topics

Animals
Chickens
DNA-Directed DNA Polymerase
Evolution, Molecular
Fungal Proteins
Gene Conversion
Humans
Immunoglobulin M
Immunoglobulins
Mice
Mutation
Phylogeny

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rabbits

Receptors, Antigen

Saccharomyces cerevisiae Proteins

Sharks

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 11205333
DOI: 10.1098/rstb.2000.0750
PMCID: PMC1087693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-11205333-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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