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Article

Functional properties of factor V and factor Va encoded by the R2-gene.

Thrombosis and haemostasis - 1 Jan 2001

Hoekema L, Castoldi E, Tans G, Girelli D, Gemmati D, Bernardi F, Rosing J

Abstract excerpt

Carriership of the factor V (FV) gene marked by the R2-haplotype, a series of linked polymorphisms encoding several amino acid changes in FV, is associated with mild resistance to activated protein C (APC) and with an increased risk of thrombosis. We compared the functional properties of normal FV(a) and R2-FV(a) in model systems and in plasma. FV and R2-FV were equally well activated by thrombin and expressed...

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Identifiers

PMID: 11204592

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APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional properties of factor V and factor Va encoded by the R2-gene.PMID 11204592Read ↗

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