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Article

Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.

Pathophysiology of haemostasis and thrombosis - 1 Jan 2010

Cramer Thomas J, Griffin John H, Gale Andrew J

Abstract excerpt

Coagulation factor V (FV) promotes inactivation of activated factor VIII (FVIIIa) by activated protein C (APC) and protein S. Loss of this APC cofactor activity is proposed to be partially responsible for the APC resistance phenotype of FV(Leiden). However, FVIIIa loses activity rapidly due to dissociation of the A2 domain, and this may be the primary mechanism of FVIIIa inactivation. APC/protein S also readily...

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Source

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Identifiers

PMID: 20501981
DOI: 10.1159/000315141
PMCID: PMC2974842

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.PMID 20501981Read ↗

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