Article
Factor V and thrombotic disease: description of a janus-faced protein.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2002
Nicolaes Gerry A F, Dahlbäck Björn
Abstract excerpt
The generation of thrombin by the prothrombinase complex constitutes an essential step in hemostasis, with thrombin being crucial for the amplification of blood coagulation, fibrin formation, and platelet activation. In the prothrombinase complex, the activated form of coagulation factor V (FVa) is an essential cofactor to the enzyme-activated factor X (FXa), FXa being virtually ineffective in the absence of its...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.