Article
Modulation of factor V levels in plasma by polymorphisms in the C2 domain.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2004
Scanavini Daniela, Girelli Domenico, Lunghi Barbara, Martinelli Nicola, Legnani Cristina, Pinotti Mirko, Palareti Gualtiero, Bernardi Francesco
Abstract excerpt
OBJECTIVE: Functional polymorphisms contributing to coagulation factor levels are preferential markers for association studies aimed at identifying prothrombic genetic components. METHODS AND RESULTS: Factor V (FV) microsatellite genotypes were found to be associated with FV levels (P=0.003). Single nucleotide polymorphisms analysis and sequencing of the promoter and of coding regions identified two polymorphisms...
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