Article
Polymorphic variation in CYP19 and the risk of breast cancer.
Carcinogenesis - 1 Feb 2001
Baxter S W, Choong D Y, Eccles D M, Campbell I G
Abstract excerpt
The production of estrogen from androgen via the estrogen biosynthesis pathway is catalyzed by aromatase P450 (cyp19). We have assessed the frequency of allelic variants of the CYP19 intron 4 [TTTA]n repeat in 327 breast cancer cases and 253 controls from southern England. Previous studies have suggested that the [TTTA](10) repeat and [TTTA](12) repeat variants represent low penetrance breast cancer...
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