Article
A rare CYP19 (aromatase) variant may increase the risk of breast cancer.
Pharmacogenetics - 1 Feb 1998
Kristensen V N, Andersen T I, Lindblom A, Erikstein B, Magnus P, Børresen-Dale A L
Abstract excerpt
The aromatase P450 (coded by the CYP19 gene) is responsible for the rate limiting step in the metabolism of C19 steroids to estrogens and is expressed in most breast carcinomas. A polymorphic tetranucleotide repeat (TTTA)n in intron 5, about 80 nucleotides downstream of exon 4 has previously been described. The allele frequencies of the polymorphic repeat were studied in series of 182 sporadic and 185 familial...
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