Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.

American journal of physiology. Renal physiology - 1 Aug 2017

Wang Liming, Sha Yonggang, Bai Jingyi, Eisner William, Sparks Matthew A, Buckley Anne F, Spurney Robert F

Abstract excerpt

Enhanced expression of cyclooxygenase 2 (COX2) in podocytes contributes to glomerular injury in diabetic kidney disease, but some basal level of podocyte COX2 expression might be required to promote podocyte attachment and/or survival. To investigate the role of podocyte COX2 expression in diabetic kidney disease, we deleted COX2 specifically in podocytes in a mouse model of Type 1 diabetes mellitus (Akita mice)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albuminuria
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Diabetic Nephropathies

Share to Integrases

Share to Mice, 129 Strain

Share to Podocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 28490532
DOI: 10.1152/ajprenal.00614.2016
PMCID: PMC5582903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.PMID 28490532Read ↗

Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice.Semantic proximity Read ↗

Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.Semantic proximity Read ↗

Model-Dependent Renal Phenotypes in Diabetic Kidney Disease: Comparative Histopathological Characterization of Commonly Used Animal ModelsSemantic proximity Read ↗

Advances in Murine Models of Diabetic NephropathySemantic proximity Read ↗

Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice.Semantic proximity Read ↗

A maladaptive role for EP4 receptors in podocytes.Semantic proximity Read ↗

Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.Semantic proximity Read ↗

Assessment of diabetic nephropathy in the Akita mouse.Semantic proximity Read ↗

Effects of the differential expression of ZO ‐1 and ZO ‐2 on podocyte structure and functionSemantic proximity Read ↗

Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury.Semantic proximity Read ↗

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy DevelopmentSemantic proximity Read ↗

Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.